State Key Laboratory of Synergistic Chem-Bio Synthesis (SKL-SCBS) leverages the combined strengths of Shanghai Jiao Tong University's three Double First-Class disciplines (Chemistry, Chemical Engineering & Technology, and Biology), the resources of the Frontiers Science Center for Transformative Molecules and the Basic Research Center for Nucleic Acid Information Materials, and the foundational research in chemical and biological synthesis from the Shanghai Key Lab. for Molecular Engineering of Chiral Drugs. The laboratory will construct and upgrade advanced research facilities. Aiming to establish a new paradigm for synergistic chem-bio matter creation and become a global hub leading innovation in synthetic science, SKL-SCBS strives to elevate the overall level and international standing of fundamental research in related fields in China. Driven by the goal of building a world-class talent ecosystem, the laboratory attracts and cultivates top-tier global talent. It places strong emphasis on recruiting and nurturing leading scientists and outstanding young researchers, striving to develop a cohort of distinguished academic leaders and promising young academic backbone members with high scholarly achievements and comprehensive excellence. SKL-SCBS actively promotes high-level academic exchanges, enhances top-tier international collaborations with leading global research institutions, and widely attracts outstanding scientific talent from home and abroad, positioning itself as a scientific highland for high-caliber researchers and a research center of significant international influence. The laboratory currently has 144 fixed researchers, including 2 CAS Academicians, 13 recipients of the National Science Fund for Distinguished Young Scholars/Chang Jiang Scholars Distinguished Professors, and 44 recipients of national young talent programs. All fixed members hold doctoral degrees, with over 65% aged 45 or younger.

With a focus on the creation of transformative drugs and biomaterials as key outputs, SKL-SCBS will address the fundamental challenge of achieving efficient chemical bond activation, cleavage, and recombination through chem-bio synergy. By integrating the advantages of chemical and biological synthesis, the laboratory will comprehensively drive the deep convergence of these fields across multiple dimensions: integration methodologies, pathways, theoretical frameworks, and practical applications.